Second Site Suppressor Mutations of a GTPase-deficient G-Protein α-Subunit
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چکیده
منابع مشابه
Second-site suppressor mutations of inactivating substitutions at gly247 of the tetracycline efflux protein, Tet(B).
An Asp or Asn substitution for Gly247 in transmembrane helix 8 (TM-8) of Tet(B), the tetracycline efflux protein, eliminated tetracycline resistance. Second site suppressor mutations which partially restored resistance were located in TM-5, -8, -10, or -11 or in cytoplasmic loop 8-9 or loop 10-11. These results indicate physical proximity or functional relationships between TM-8 and these other...
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Alexander DIETRICH*1, Alexander SCHEER†2, Daria ILLENBERGER*, Yoel KLOOG‡, Yoav I. HENIS‡ and Peter GIERSCHIK*3 *Department of Pharmacology and Toxicology, University of Ulm, 89069 Ulm, Germany, †Institute of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland, and ‡Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv...
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We have solved the crystal structures of three oncogenic mutants of the core domain of the human tumor suppressor p53. The mutations were introduced into a stabilized variant. The cancer hot spot mutation R273H simply removes an arginine involved in DNA binding without causing structural distortions in neighboring residues. In contrast, the "structural" oncogenic mutations H168R and R249S induc...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.44.28597